| 名稱 | PTEN p.R130* Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10120 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | PTEN p.R130* Reference Standard |
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10120PTEN p.R130* Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
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CBP10120 | |
| Format | Genomic DNA |
| Description | PTEN R130* results in a premature truncation of the Pten protein at amino acid 130 of 403 within the phosphatase tensin-type domain (UniProt.org). R130* confers a loss of function to the Pten protein as demonstrated by decreased p53 signaling and increased DNA damage in xenografts (PMID: 24721394) and increased transformation ability in two different cell lines, as compared to wild-type Pten (PMID: 29533785). |
| Technical Data | |
| DNA Change: | c.388C>T |
| AA Change | p.R130* |
| Mutation type | Substitution - Nonsense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000371953 |
| Cosmic ID | COSM5152 |
| Chr position(GRCh37) | chr10:89692904 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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