| 名稱 | TP53 p.R248Q Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10140 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | TP53 p.R248Q Reference Standard |
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基因檢測標(biāo)準(zhǔn)品 > Mutation > CBP10140TP53 p.R248Q Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
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CBP10140 | |
| Format | Genomic DNA |
| Description | TP53 R248Q is a hotspot mutation that lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). R248Q results in decreased transactivation of Tp53 targets and interference with wild-type Tp53 transactivation in cell culture, as well as increased Akt activation and enhanced tumor onset and growth in mouse models (PMID: 23538418, PMID: 16861262). |
| Technical Data | |
| DNA Change: | c.743G>A |
| AA Change | p.R248Q |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM10662 |
| Chr position(GRCh37) | chr17:7577538 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |
|
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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